New classes

  1. "imaging technique" (code: NPO_1477)
  2. "diagnostic imaging" (code: NPO_1478)
  3. "tomography" (code: NPO_1479)
  4. "computed tomography" (NPO_1480)
  5. "single photon emission computed tomography" (code: NPO_1481)
  6. "positron emission tomography" (code: NPO_1482)
  7. "magnetic resonance imaging" code: (NPO_1483)
  8. "ultrasound imaging" (code: NPO_1484)
  9. "titanium  oxide" (code: NPO_1485)
  10. "titanium oxide nanoparticle" (code: NPO_1486)
  11. "sample" (code: NPO_1487)
  12. "sample composition" (code: NPO_1488)
  13. "sample preparation" (code: NPO_1489)
  14. "nanoparticle property" (code: NPO_1490)
  15. "nanoparticle in sample" (code: NPO_1491)
  16. "functionalizing agent" (code: NPO_1492)
  17. "functionalizing component in nanoparticle sample" (code: NPO_1493)
  18. "nanomaterial component" (code: NPO_1494)
  19. "nanoparticle sample component" (code: NPO_1495)
  20. "nanoparticle component" (code: NPO_1496)
  21. "chemical component" (code: NPO_1497)
  22. "monomer" (code: NPO_1498)
  23. "repeat unit" (code: NPO_1499)
  24. "substance" (code: NPO_1500)
  25. fluid state  (code: NPO_1501)
  26. gaseous state (code: NPO_1502)
  27. vapor state (code: NPO_1503)
  28. liquid state (code: NPO_1504)
  29. state of mixture (code: NPO_1505)
  30. state of suspension (code: NPO_1506)
  31. colloidal state (code: NPO_1507)
  32. state of emulsion (code: NPO_1508)
  33. gel state (code: NPO_1509)
  34. state of sol (code: NPO_1510)
  35. solid state (code: NPO_1511)
  36. crystalline state (code: NPO_1512)
  37. glassy state (code: NPO_1513)
  38. granular state (code: NPO_1514)
  39. powdered state (code: NPO_1515)
  40. imaging (code:NPO_1516)
  41. study (code: NPO_1517)
  42. pharmacokinetic study (code: NPO_1518)
  43. pharmacological study (code:NPO_1519)
  44. toxicological study (code:NPO_1520)
  45. pharmacokinetic property (code:NPO_1521)
  46. elimination half life (code:NPO_1522)
  47. area under the plasma concentration time curve (code: NPO_1523)
  48. volume of distribution (code: NPO_1524)
  49. clearance (code: NPO_1525)
  50. elimination rate constant (code: NPO_1526)
  51. Cmax (code: NPO_1527)
  52. Tmax (code: NPO_1528)
  53. bioavailability (code:NPO_1529)
  54. pharmacokinetic parameter (code:NPO_1530)
  55. tumor imaging (code: NPO_1531)
  56. detection of tumors (code:NPO_1532)
  57. therapeutic payload (code:NPO_1533)
  58. imaging payload (code:NPO_1534)
  59. tumor angiogenesis (code:NPO_1535)
  60. inorganic nanoparticle (code: NPO_1536)
  61. superparamagnetic nanoparticle (code:NPO_1537)
  62. pH-sensitive polymeric nanoparticle (code:NPO_1538)
  63. particle diameter (code: NPO_1539)
  64. metal oxide (code: NPO_1540)
  65. metal oxide nanoparticle (code: NPO_1541)
  66. zinc oxide nanoparticle (code: NPO_1542)
  67. zinc oxide (code: NPO_1543)
  68. copper oxide nanoparticle (code: NPO_1544)
  69. copper oxide (code: NPO_1545)
  70. copper I oxide (code: NPO_1546)
  71. copper II oxide (code: NPO_1547)
  72. iron (II, III) oxide nanoparticle (code: NPO_1548)
  73. dextran-coated iron oxide nanoparticle (code: NPO_1549)
  74. iron (III) oxide nanoparticle (code: NPO_1550)
  75. spherical nanoparticle (code: NPO_1551)
  76. lipid nanoparticle (code: NPO_1552)
  77. fluorescent silica nanoparticle (code: NPO_1553)
  78. gelatin (code: NPO_1554)
  79. gelatin nanoparticle (code: NPO_1555)
  80. poly(lactic-co-glycolic acid) (code: NPO_1556)
  81. lactic acid (code: NPO_1557)
  82. glycolic acid (code: NPO_1558)
  83. PLGA nanoparticle (code: NPO_1559)
  84. oxygen hydride (code: NPO_1560)
  85. water (code: NPO_1561)
  86. fluorescent core-shell nanoparticle (code: NPO_1562)
  87. mineral (code: NPO_1563)
  88. phosphate mineral (code: NPO_1564)
  89. apatite (code: NPO_1565)
  90. hydroxyapatite (code: NPO_1566)
  91. inorganic group (code: NPO_1567)
  92. hydroxyapatite nanoparticle (code: NPO_1568)
  93. gadolinium-loaded nanoparticle (code: NPO_1569)
  94. gadolinium ion (code: NPO_1570)
  95. chitosan-coated magnetic nanoparticle (code: NPO_1571)
  96. core-shell silica nanoparticle (code: NPO_1572)

New object properties (class-level associations)

  1. quality_inheres_in
  2. has_technique
  3. technique_used_for
  4. parameter determined from
  5. property determined from

Changes to object properties from previous version (2009-08-05)

New annotation properties

Changes to annotation properties from previous version (2009-08-05)

  1. removed annotation property "last modified" because of zero usage.
  2. deleted the usage of code in the annotation of "code" property,  and added rdfs:label for "code". 

New class-level assertions to existing classes

  1. "sample" has_quality "sample composition"
  2. "nanoparticle sample" has_quality "sample composition
  3. "nanoparticle" has_quality "nanoparticle property"
  4. "nanoparticle property" quality_inheres_in "nanoparticle"
  5. "nanoparticle formulation" has_quality "physical state"
  6. "dendrimer" has_part "molecular component in dendrimer"
  7. "molecular component in dendrimer" part_of "dendrimer"
  8. "polymer" has_component_part "monomer"
  9. "polymer" has_part "repeat unit"
  10. "dendrimer" has_part" "dendrimer repeat unit"
  11. "nanomaterial" has_quality "physical state"
  12. "sample" has_quality "physical state"
  13. "fluid" has_quality  "fluid state"
  14. "gas" has_quality "gaseous state" 
  15. "vapor"  has_quality "vapor state"
  16. "liquid" has_quality "liquid state" 
  17. "mixture"has_quality  "state of mixture" 
  18. "suspension" has_quality "state of suspension" 
  19. "colloid" has_quality "colloidal state" 
  20. "emulsion" has_quality "state of emulsion"
  21. "gel" has_quality "gel state" 
  22. "sol" has_quality "state of sol" 
  23. "solid" has_quality "solid state" 
  24. "crystal" has_quality "crystalline state" 
  25. "glass" has_quality "glassy state 
  26. "granule" has_quality  "granular state" 
  27. "powder" has_quality "powdered state"
  28. "fluid state" quality_inheres_in "fluid"
  29. "gaseous state" quality_inheres_in "gas" 
  30. "vapor state"  quality_inheres_in "vapor"
  31. "liquid state" quality_inheres_in "liquid" 
  32. "state of mixture" quality_inheres_in  "mixture" 
  33. "state of suspension" quality_inheres_in "suspension" 
  34. "colloidal state" quality_inheres_in "colloid" 
  35. "state of emulsion" quality_inheres_in "emulsion"
  36. "gel state" quality_inheres_in "gel" 
  37. "state of sol" quality_inheres_in "sol" 
  38. "solid state" quality_inheres_in "solid" 
  39. "crystalline state" quality_inheres_in "crystal" 
  40. "glassy state" quality_inheres_in "glass" 
  41. "granular state" quality_inheres_in  "granule" 
  42. "powdered state" quality_inheres_in "powder"
  43. "substance" has_quality "amount of substance"
  44.  "nanoemulsion" has_quality "state of emulsion"
  45.  "emulsion" has_part (molecular structure and (has_role emulsifier))
  46. "nanoparticle" has_quality "particle diameter"
  47. "drug toxicity" quality_inheres_in "anticancer drug"
  48. added synonym "ZnS quantum dot" for class "zinc sulfide quantum dot" (code: NPO_193)
  49. added synonym "CdSe quantum dot" for class "cadmium selenide quantum dot" (code: NPO_160)
  50. added synonym "Au quantum dot" for class "gold quantum dot" (code: NPO_186)
  51. "cellular component" (code: NPO_1008) part_of "cell" (code: NPO_1009)
  52. "hydrogel nanoparticle" (code: NPO_1378) has_quality "gel state" (code: NPO_1509)
  53. "hydrogel nanoparticle" (code: NPO_1378) has_part "water" (code: NPO_1561)
  54. made classes "anion" (code: NPO_1030) and "cation" (code: NPO_1029) disjoint.

Changes to class-level annotations and assertions of the previous version (2009-08-05)

  1. changed parent class of "nanoparticle sample" (code: NPO_1404) from "nanomaterial" (code: NPO_199) to "nanoparticle formulation" (code: NPO_868).
  2. changed parent class of "nanoemulsion" (code: NPO_393) from "emulsion" (code: NPO_639) to "nanoparticle formulation" (code: NPO_868).
  3. change name "molecular role in dendrimer" to "molecular component in dendrimer" (code: NPO_180), and its parent class to "chemical component"
  4. changed definition of "dendrimer core molecule" (code: NPO_803)
  5. changed definition of "dendrimer end group" (code: NPO_695)
  6. changed definition of "dendrimer repeat unit" (code: NPO_621)
  7. removed "has_role" from the assertions for "polyamidoamine dendrimer" (code: NPO_965)
  8. changed parent class of "dendrimer repeat unit" to "repeat unit"
  9. moved subclasses of "physical state" (e.g., fluid, gas, solid, etc.) and placed them under "substance"; modified definitions of these subclasses
  10. created new subclasses of physical state: e.g., fluid state, gaseous state, solid state, etc.
  11. replaced "Nanoparticle Payload Agent" with "therapeutic payload" in the assertions of "drug-loaded nanoparticle", "doxorubicin-loaded nanoparticle", "tamoxifen-loaded nanoparticle", "methotrexate-loaded nanoparticle", "paclitaxel-loaded nanoparticle", "etoposide-loaded nanoparticle"
  12. added synonym "chemotherapeutic agent" for class "anticancer drug" (code:NPO_312)
  13. modified definition of "isotope" (code: NPO_973)
  14. changed "molecule role" to "molecular role", and removed synonym "role of molecular entity". Also, modified definition.
  15. modified definition of "chemiluminescence" (code: NPO_1402)
  16. changed parent class of "cell" from "cellular component" to "material entity". Modified definition of cell.
  17. changed preferred name "target" (code: NPO_830) to "target molecule"
  18. modified definition of "nanomaterial" (code: NPO_199)
  19. replaced "mainly" with "basically" in the definition of "chitosan nanoparticle" (code: NPO_261)
  20. replaced "mainly" with "basically" in the definition of "gold nanoparticle" (code: NPO_401)
  21. replaced "mainly" with "basically" in the definition of "gold quantum dot-entrapped poly(amidoamine) dendrimer" (code: NPO_551)
  22. replaced "mainly" with "basically" in the definition of "iron oxide nanoparticle" (code: NPO_729)
  23. replaced "mainly" with "basically" in the definition of "metal nanoparticle" (code: NPO_1384)
  24. replaced "mainly" with "basically" in the definition of "polymeric nanoparticle" (code: NPO_1375)
  25. replaced "mainly" with "basically" in the definition of "silica dioxide nanoparticle" (code: NPO_1373)
  26. replaced "mainly" with "basically" in the definition of "solid lipid nanoparticle" (code: NPO_631)

Usage of class-level associations

No.preferred NameNo. of times used between classesUsage valid for classes 
(shown below are the top-level classes of these classes)Examples1.has relation to0entity -> entity-2.part of82continuant -> continuant 
occurrent -> occurrenthollow core of nanocage part of nanocage3.is integral part of223atom -> elementcarbon atom is integral part of carbon4.has part267continuant -> continuant 
occurrent -> occurrentgold quantum dot has part gold5.has component part44nanomaterial -> molecular structure 
nanomaterial -> nanomaterialchitosan nanoparticle has component part chitosan6.has conjugated component part0nanomaterial -> molecular structure 
nanomaterial -> nanomaterial-7.has encapsulated component part0nanomaterial -> molecular structure 
nanomaterial -> nanomaterial-8.has entrapped component part1nanomaterial -> molecular structure 
nanomaterial -> nanomaterialgold quantum dot-entrapped poly(amidoamine) dendrimer nanoparticle has entrapped component part (gold quantum dot and participates in entrapment)9.has role66molecular structure -> molecule roledoxorubicin has role topoisomerase-II inhibitor10.has quality114continuant -> quality 
occurrent -> qualitybiodegradable nanoparticle has quality biodegradable11.has function realized as process8molecule role -> occurrent 
material entity -> occurrentangiogenesis inhibitor has function realized as process angiogenesis inhibition12.inhibits17molecule role -> occurrent 
material entity -> occurrenttopoisomerase-II inhibitor inhibits DNA topoisomerase-II activity13.regulates1molecule role -> occurrent 
material entity -> occurrentDNA-RNA transcription regulator regulates DNA-dependent transcription14.participates in16molecule role -> occurrent 
material entity -> occurrentgold quantum dot-entrapped poly(amidoamine) dendrimer nanoparticle has component part(polyamidoamine dendrimer and participates in entrapment)15.has participant51occurrent -> molecule role 
occurrent -> material entityamide linkage between primary amine and carboxylic acid has participant primary amine grouphas participant carboxyl group16.has output participant23occurrent -> molecule role 
occurrent -> material entityamide linkage between primary amine and carboxylic acid has output participantcarboxamide group17.stimulus causes response3stimulus for nanoparticle function ->nanoparticle response to stimulusstimulus of infrared light stimulus causes response nanoparticle response to infrared light18.describes property5characterization -> qualitysize characterization describes property size19.has unit of measure39quality -> unit of measurementlength has unit of measure length unit20.unit of31unit of measurement -> qualitylength unit unit of length21.has bond with2between atom classes which are part of apolyatomic entity classorganonitrogen compound has part (carbon atom and has bond with nitrogen atom22.has single bond with2between atom classes which are part of apolyatomic entity classchlorambucil has part (carbon atom and has single bond with chlorine atom23.has double bond with0between atom classes which are part of apolyatomic entity class-24.has triple bond with0between atom classes which are part of apolyatomic entity class-

Number of times class-level associations are used

No. preferred name version 2009-09-28
1 has relation to 0
2 part of 82
3 is integral part of 223
4 has part 267
5 has component part 44
6 has conjugated component part 0
7 has encapsulated component part 0
8 has entrapped component part 1
9 has role 66
10 has quality 113
11 has function realized as process 8
12 inhibits 17
13 regulates 1
14 participates in 16
15 has participant 51
16 has output participant 23
17 stimulus causes response 3
18 determines property 5
19 has unit of measure 39
20 unit of 31
21 has bond with 2
22 has single bond with 2
23 has double bond with 0
24 has triple bond with 0
25 has function 5
26 function of 1
27 has application 1
28 uses instrument 12
29 quality inheres in 18
30 has technique 1
31 technique used for 1
32 parameter determined from 8
33 property determined from 1