No. | Code | Name | CLASS-LEVEL ANNOTATION | CLASS-LEVEL ASSERTION |
|---|
| new class-level annotation | changes to class-level annotation from previous version (2009-09-28) | new class-level assertion | changes to class-level assertion from previous version (2009-09-28) |
| 1 | NPO_1378 | HYDROGEL NANOPARTICLE | | changed definition from "A nanoparticle which exists as part_of a hydrogel" to "A nanoparticle which exists while dispersed in hydrogel". | part_of some HYDROGEL | deleted "has_part some WATER"; deleted "has_quality some GEL STATE" . [Reason for both changes: nanoparticle is part_of a hydrogel] |
| 2 | NPO_1489 | SAMPLE PREPARATION | | | part_of some STUDY | |
| 3 | NPO_1355 | CHARACTERIZATION | | | part_of some STUDY; has_part some ASSAY | |
| 4 | NPO_1356 | PHYSICOCHEMICAL CHARACTERIZATION | | | has_part some PHYSICOCHEMICAL ASSAY | |
| 5 | NPO_1357 | IN VITRO CHARACTERIZATION | | | has_part some IN VITRO ASSAY | |
| 6 | NPO_1358 | IN VIVO CHARACTERIZATION | | | has_part some IN VIVO ASSAY | |
| 7 | NPO_1220 | TUMOR WEIGHT | | | quality_of some TUMOR | |
| 8 | NPO_1337 | TUMOR VOLUME | | | quality_of some TUMOR | |
| 9 | NPO_1009 | CELL | | | has_part some INTRACELLULAR SPACE | |
| 10 | NPO_493 | RECEPTOR | | changed definition [reason for change: use definition from UniProtKB]; removed "is the role_of a molecular entity that" from definition | has_function (FUNCTION and (is_realized_in RECEPTOR ACTIVITY)); has_function (BINDING FUNCTION and (is_realized_as RECEPTOR BINDING)) | changed parent class from PROTEIN ROLE to PROTEIN. [Reason for change: RECEPTOR is not a role but an independent continuant, which can be asserted as a defined class]. |
| 11 | NPO_681 | DIAGNOSTIC IMAGING AGENT | | | has_application some DIAGNOSTIC IMAGING | changed parent class from MOLECULE ROLE IN DIAGNOSTIC IMAGING to MOLECULAR ENTITY; [Reason for change: DIAGNOSTIC IMAGING AGENT is not a role but an independent continuant, which can be asserted as a defined class]. |
| 12 | NPO_581 | MRI CONTRAST AGENT | | | has_application some MAGNETIC RESONANCE IMAGING | |
| 13 | NPO_250 | ULTRASOUND CONTRAST AGENT | | | has_application some ULTRASOUND IMAGING | |
| 14 | NPO_166 | FLUORESCENCE IMAGING CONTRAST AGENT | | | has_application some FLUORESCENCE IMAGING | |
| 15 | NPO_1490 | NANOPARTICLE PROPERTY | | | inheres_in some (NANOPARTICLE or NANOPARTICLE FORMULATION) | removed "quality_of some NANOPARTICLE" [reason for change: use inheres_in instead of "quality_of" to be more generic. quality_of is a subproperty of inheres_in" changed parent class of NANOPARTICLE PROPERTY from QUALITY OF CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT [reason for change: an instance of a property can be an instance of QUALITY or REALIZABLE ENTITY. So the change will enable one to use NANOPARTICLE PROPERTY as a defined class to classify all subclasses of QUALITY and REALIZABLE ENTITY] |
| 16 | NPO_903 | ACTIVE TARGETING | | | has_participant some (MOLECULAR ENTITY and has_role some TARGETING ROLE) | |
| 17 | NPO_643 | FLUOROCHROME | | | has_property some FLUORESCENT; has_application some (FLUORESCENCE MICROSCOPY or FLUORESCENCE IMAGING or FLUORESCENCE SPECTROSCOPY) | changed parent class to FLUORESCENT DYE |
| 18 | NPO_685 | TARGETING AGENT | | modified definition [reason for change: parent class is changed] | has_role some TARGETING ROLE; participates_in some ACTIVE TARGETING; has function some TARGETING FUNCTION | changed parent class from MOLECULAR TARGETING ROLE to MOLECULAR ENTITY; made TARGETING AGENT a defined class. [reason for change: it is not a role but an independent continuant which is a defined class by virtue of it having a targeting function] |
| 19 | NPO_1497 | CHEMICAL COMPONENT | | replaced "component" with "material entity" in the definition | part_of only (MOLECULAR STRUCTURE or NANOMATERIAL) | |
| 20 | NPO_195 | LINKAGE | | | has_part only CHEMICAL INTERACTION | |
| 21 | NPO_695 | DENDRIMER END GROUP | | | has_identification_type exactly 1 FUNCTIONAL GROUP; has_identification_type only FUNCTIONAL GROUP | |
| 22 | NPO_803 | DENDRIMER CORE MOLECULE | | | has_identification_type some COMPOUND or MOLECULE; has_identification_type only COMPOUND or MOLECULE | |
| 23 | NPO_1493 | FUNCTIONALIZING AGENT | | changed rdf:ID from FUNCTIONALIZING COMPONENT IN NANOPARTICLE SAMPLE to FUNCTIONALIZING AGENT changed preferred name to "functionalizing agent" modified definition | participates_in some FUNCTIONALIZATION OF NANOPARTICLE; has_role some FUNCTIONALIZING ROLE | changed parent class from CHEMICAL COMPONENT IN NANOPARTICLE SAMPLE to MOLECULAR ENTITY removed "part_of some NANOPARTICLE SAMPLE" |
| 24 | NPO_1495 | MOLECULAR COMPONENT IN NANOPARTICLE | | changed class name (rdf:ID, preferred name) from NANOPARTICLE SAMPLE COMPONENT to MOLECULAR COMPONENT IN NANOPARTICLE; removed synonym; changed definition | part_of only NANOPARTICLE COMPONENT; part_of exactly 1 NANOPARTICLE COMPONENT | |
| 25 | NPO_868 | NANOPARTICLE FORMULATION | | | has_component_part only (CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION or NANOPARTICLE or MOLECULAR STRUCTURE); has_component_part some (NANOPARTICLE or NANOPARTICLE COMPONENT) | |
| 26 | NPO_943 | SINGLE-WALLED CARBON NANOTUBE | added synonym "SWCNT" | | | |
| 27 | NPO_1355 | NANOPARTICLE CHARACTERIZATION | added synonym "characterization of nanoparticle" | | | |
| 28 | NPO_563 | COVALENT LINKAGE | added synonym "covalent conjugation" | | | |
| 29 | NPO_1522 | ELIMINATION HALF LIFE | added synonym "biological half life"; added dBXrefID "NCIT:C70915" | changed definition [reason for change: to agree with the NCIT definition]; removed synonym "plasma half life" [reason for change: not specific for this class] | | |
| 30 | NPO_112 | MULTI-WALLED CARBON N ANOTUBE | added synonym "MWCNT" | | | |
| 31 | NPO_362 | MOLECULAR FUNCTION | added synonym "molecular activity" | | | |
| 32 | NPO_1409 | IN VITRO ASSAY | | changed preferred name from IN VITRO BIOASSAY to IN VITRO ASSAY. [reason for change: commonly used, used in caNanoLab]; changed synonym to "in vitro bioassay" | | |
| 33 | NPO_1410 | IN VIVO ASSAY | | changed preferred name IN VIVO BIOASSAY to IN VIVO ASSAY [reason for change: commonly used, used in caNanoLab]; changed synonym to "in vivo bioassay" | | |
| 34 | NPO_1408 | ASSAY | | changed the word "quality" to "property" in the definition [reason for change: for sake of clarity] | | |
| 35 | NPO_752 | INTERNAL STIMULUS FOR NANOPARTICLE FUNCTION | | changed the first letter of every word from capital to small case in the preferred name | | |
| 36 | NPO_707 | NANOPARTICLE | | modified definition [reason for change: for clarity] | | removed "has_quality some NANOPARTICLE PROPERTY" |
| 37 | NPO_227 | TARGETING LIGAND | | removed "is role_of" from definition [reason for change: it is an independent continuant] | | |
| 38 | NPO_1396 | IMAGING FUNCTION | | replaced "continuant" with "material entity" in the definition [Reason for change: to be more specific] | | |
| 39 | NPO_1395 | TARGETING FUNCTION | | replaced "continuant" with "material entity" in the definition [Reason for change: to be more specific] | | removed "function_of TARGETING AGENT" |
| 40 | NPO_1397 | THERAPEUTIC FUNCTION | | replaced "continuant" with "material entity" in the definition [Reason for change: to be more specific] | | |
| 41 | NPO_468 | MOLECULAR ROLE | | replaced "material entity" with "independent continuant" in the definition | | |
| 42 | NPO_1494 | CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION | | changed preferred name NANOMATERIAL COMPONENT to CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION; removed synonym "component of nonmaterial" | added "part_of some NANOPARTICLE FORMULATION"; added part_of only NANOPARTICLE FORMULATION | removed "part_of some NANOMATERIAL" |
| 43 | NPO_1496 | NANOPARTICLE COMPONENT | | changed definition; removed synonym "component of nanoparticle" | has_identification_type only NANOPARTICLE; has_identification_type some MOLECULAR STRUCTURE; has_component_part only MOLECULAR COMPONENT IN NANOPARTICLE; has_component_part some MOLECULAR COMPONENT IN NANOPARTICLE; has_conjugated_component_part only MOLECULAR COMPONENT IN NANOPARTICLE; has_encapsulated_component_part only MOLECULAR COMPONENT IN NANOPARTICLE; has_entrapped_component_part only MOLECULAR COMPONENT IN NANOPARTICLE; | |
| 44 | NPO_1491 | MOLECULAR COMPONENT IN NANOPARTICLE FORMULATION | | changed class name (rdf:ID, preferred name) from NANOPARTICLE IN SAMPLE to MOLECULAR COMPONENT IN NANOPARTICLE FORMULATION; modified definition | has_identification_type only MOLECULAR ENTITY; has_identification_type some MOLECULAR ENTITY; has_property onlySPECIFICALLY DEPENDENT CONTINUANT | changed parent class from NANOPARTICLE to CHEMICAL COMPONENT IN NANOPARTICLE FORMULATION |
| 45 | NPO_1422 | ANALYSIS | | | | changed parent class from PROCESS to STUDY. [Reason for change: based on the definition for study, analysis is a type of study] |
| 46 | NPO_380 | GADOLINIUM | | | | removed assertion "has_role some MRI CONTRAST AGENT" [Reason for change: not true at the class-level] |
| 47 | NPO_445 | QUALITY | | inserted "specifically" in the definition | | changed parent class from DEPENDENT CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT. [reason for change: for compliance with BFO] |
| 48 | NPO_237 | REALIZABLE ENTITY | | | | changed parent class from DEPENDENT CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT. [reason for change: for compliance with BFO] |
| 49 | NPO_1153 | UNIT OF MEASUREMENT | | | | changed parent class from DEPENDENT CONTINUANT to SPECIFICALLY DEPENDENT CONTINUANT. [reason for change: for compliance with BFO] |
| 50 | NPO_199 | NANOMATERIAL | | | | removed "has_part some CHEMICAL COMPONENT IN NANOMATERIAL" removed "has_quality some PHYSICAL STATE" |